Who are our donors and how we examine them
Voluntary donors are young women under 32 years of age. Our clinic uses only eggs from young healthy donors and never uses surplus eggs from our patients. To enter the donation programme the donor must meet very strict criteria defined by the European directives.
Besides ultrasound examination and genetic interview the donors are repeatedly tested for sexually transmitted diseases (HIV, HBV, HCV, Syphilis).
We also examine their karyotype and genetic makeup,
looking specifically for gene mutation causing cystic fibrosis and spinal muscular atrophy. Most of our donors are also often mothers on maternity leave. None of them is treated at our clinic with infertility issue and oocyte donation is their voluntary decision. According to the Czech law oocyte donation is completely anonymous. It is strictly forbidden to facilitate any meetings between the donor and the recipient.
The physician selects the donors well
in advance to achieve the highest possible matching with the recipient’s requirements. All donors must have a full 12-year education. The absolute majority of our male and female donors are citizens of the Czech Republic.
Do I get any detailed information about the egg donor?
The anonymity of reproductive cell donors is required by Czech legislation (Act No. 373/2011 Coll. on specific medical services). Since 2010 donors are protected through provision of only limited information about them - their year of birth and blood group. Other detailed information (eye and hair colour, body height and weight) about the male and female donors will not be provided to the patients.
Method of searching for egg donors
Since 2006 our clinic includes a specialised team focusing on donation programme. The method of selecting donors is highly sophisticated.
The selection of egg donors meets the requirements of Act No 296/2008 Coll. and Regulation No 422/2008 Coll., as well as Act No 373/2011 Coll. These laws constitute the common European Tissue Directive No 2004/23/EC and adherence to the regulations thereof in the Czech Republic is supervised by the State Institute for Drug Control (SÚKL).
Since 2006 more than six thousand voluntary egg donors came to our clinic.
Over 1,500 women come to donate eggs every year. However, approximately 40 % of them are refused during the process of examination.
The system of selecting the right donor consists of several process steps:
- Initial information interview and filling of questionnaires (medical condition, education, interests, family medical history).
- Drug abuse examination.
- Blood sampling to test for infections, genetics and indicators of ovarian reserve.
- Consultation genetics.
- Consultation with our physician and gynaecological examination.
- Evaluation of test results and assessment of aptitude for donation.
- Planning of term for donation and explanation of stimulation, synchronisation and matching (of suitable donor with recipient).
- Stimulation process and egg retrieval:
- instruction and application of stimulating injections and plan of stimulation,
- monitoring during the stimulation,
- egg retrieval,
- check-up e-mail after end of stimulation.
From initial interview to the donation the entire process takes 2-3 months.
List of performed genetic tests:
- karyotype (46 XY)
- spinal muscular atrophy
- cystic fibrosis
(mutations: Tn IVS8 36 standard mutations (F508del, G542X, N1303K, W1282X, G551D, 1717-1GtoA, R553X, CFTRdele2,3(21kb), I507del, 711 1GtoT, 3272-26AtoG, 3905insT, R560T, 1898 1GtoA, S1251N, I148T, 3199del6, 3120 1GtoA and Q552X 621 1GtoT, 3849 10kbCtoT, 2183AAtoG, 394delTT, 2789 5GtoA, R1162X, 621 3659delC, R117H, R334W, R347P, G85E, 1078delT, A455E, 2143delT, E60X, 2184delA, 711 5GtoA)
Further tests if required by the recipients are not included in the price of treatment and must be paid separately (e.g.: Tay-Sachs, FRAX and other tests).
We do believe that you will be satisfied with our care and attitude.
MUDr. Štěpán Machač, PhD.